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Bold support for

a bold mouthwash

LISTERINE® is an extensively researched mouthwash brand, with over 4 decades of clinical support. Bold evidence like this proves that better oral health is not only possible, but achievable.

 Adjunctive Benefit of an Essential Oil-containing Mouthrinse in Reducing Plaque and Gingivitis in Patients Who Brush and Floss Regularly: A Six-Month Study1 

- Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135:496-504.

 Benefits of LISTERINE®: Oral Hygiene Routine Study 

 Objective 

Determine the incremental benefit of the adjunctive use of an essential oil-containing mouthrinse (LISTERINE® COOL MINT®) to routine brushing and flossing in inhibiting whole-mouth plaque and gingivitis (N=237).

 Methodology 

Randomized, controlled, observer-blind, parallel-group clinical study of subjects with mild-to-moderate gingivitis.

 Results 

Whole-mouth mean Plaque Index score at 6 months: BFEO rinse group experienced 56.3% reduction versus BC.

Whole-mouth mean Modified Gingival Index score at 6 months: BFEO rinse group experienced 29.9% reduction versus BC.

B=Brushing.
F=Flossing.
C=Rinsing with control mouthrinse.
EO=Rinsing with an essential oil-containing mouthrinse.

 Conclusion 

This long-term study demonstrates that the adjunctive use of an essential oil-containing mouthrinse twice daily provides a meaningful and clinically significant incremental benefit to a recommended regimen of brushing twice daily and flossing once daily.

*LISTERINE® is not indicated for use in the treatment of xerostomia.

 Reference: 1.  Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. J Am Dent Assoc. 2004;135:496-504.

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Site last updated: July 06, 2026

Disclaimer: Advice on oral care provided on this site is not intended as a substitute for professional medical/dental advice, diagnosis, or treatment.

Always seek the advice of your physician, dental professional, or other qualified health provider with any questions you may have regarding a medical/dental condition.